Sergio Leone
Director
Claudia Cardinale
Jill McBain
Henry Fonda
Frank
Jason Robards
Manuel 'Cheyenne' Gutiérrez
Charles Bronson
Harmonica
Gabriele Ferzetti
Morton - Railroad Baron
Paolo Stoppa
Sam
Woody Strode
Stony - Member of Frank's Gang
Jack Elam
Snaky - Member of Frank's Gang
Keenan Wynn
Sheriff - Auctioneer
Frank Wolff
Brett McBain
Lionel Stander
Barman
Livio Andronico
Bit part
Salvatore Basile
Member of Cheyenne's Gang
Aldo Berti
Member of Frank's Gang Playing Poker
Joseph Bradley
Train Station Master
Frank Braña
Member of Frank's Gang Smoking Pipe at Auction
Marilù Carteny
Mourner at Brett McBain's Funeral
Saturno Cerra
Member of Frank's Gang on Train
Luigi Ciavarro
Older Sheriff's Deputy
Spartaco Conversi
Member of Frank's Gang Shot Through Boot
Bruno Corazzari
3rd Member of Cheyenne's Gang
Bill Crawley
Railway Worker
Paolo Figlia
Member of Frank's Gang
John Frederick
Jim - Member of Frank's Gang
Don Galloway
Member of Frank's Gang in Flashback
Michael Harvey
Frank's Lieutenant
Robert Hossein
Member of Frank's Gang in Flashback
Stefano Imparato
Patrick McBain
Francesca Leone
Girl at Flagstone Station
Raffaella Leone
Girl at Flagstone Station
Frank Leslie
Member of Frank's Gang in Flashback
Luigi Magnani
Unconfirmed Role
Claudio Mancini
Harmonica's Brother
Dino Mele
Harmonica as a Boy
Antonio Molino Rojo
Member of Frank's Gang at Auction
Enrico Morsella
Member of Frank's Gang in Flashback
Umberto Morsella
Member of Frank's Gang in Flashback
Al Mulock
Knuckles - Member of Frank's Gang
Ricardo Palacios
Morton's Train Conductor
Tullio Palmieri
Flagstone Carpenter
Antonio Palombi
Cattle Corner Station Agent
Renato Pinciroli
First Bidder at Auction
Lorenzo Robledo
2nd Member of Cheyenne's Gang
Sandra Salvatori
Mourner at Brett McBain's Funeral
Aldo Sambrell
Cheyenne's Lieutenant
Conrado San Martín
Vecino
Enzo Santaniello
Timmy McBain
Simonetta Santaniello
Maureen McBain
Claudio Scarchilli
Member of Frank's Gang
Giovanni Ivan Scratuglia
Sheriff's Deputy
Robert Spafford
Construction Yard Owner
Benito Stefanelli
Frank's Lieutenant
Luana Strode
Indian Woman at Cattle Corner Station
Fabio Testi
Member of Frank's Gang with Black Hat at Auction
Dino Zamboni
Man in the Bar
Marco Zuanelli
Wobbles